In 2017, Tanzania was among the seven countries accounted for fifty three percent of all global malaria deaths by five percent. In other words, vector control and antimalarial drugs have insufficiently controlled malaria morbidity and mortality. Hence, there is a need of adding other interventions such as malaria vaccine.Despite that, there is no available perfect effective malaria vaccine to date but promising malaria vaccines candidates are still entering the clinical trials. RTS, S is the first licensed malaria vaccine and currently administered in children up to two years in Malawi, Ghana and Kenya. The vaccine is imperfect with almost forty percent effectiveness but will at least lower malaria incidences and health-associated problems in children when compared to the standard care.